Various organs such as the intestine and lungs are covered with thin-film epithelial tissue. In normal epithelial tissue, cells are neatly arranged. In the early stage of cancer cell metastasis, the epithelial cells will be deformed after being stimulated, and then the epithelial tissue will become fragmented and become the cause of canceration and cancer cell metastasis. However, researchers have been unclear about the mechanism by which epithelial tissue can remain in good condition.
A research team led by Professor Takahashi Takahashi of Kyoto University in Japan found that if the renal tubules in the chicken embryo were removed, the epithelial cells adjacent to the renal tubules would be deformed, and then implanted with oncogenes. After applying stimulation, the epithelial cells would become fragmented. , The phenomenon of cancer metastasis.
However, if the renal tubules are preserved, the epithelial cells will not become fragmented even if oncogenes are implanted into the epithelial cells. The researchers pointed out that this is because the renal tubules can make fibronectin, fill the gaps between cells, and promote the growth of cell adhesion, so that the adjacent epithelial tissue remains normal and prevents the metastasis of cancer cells.
The researchers said that using fibronectin is expected to develop cancer treatments with fewer side effects to prevent cancer cell metastasis.
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