Reveal the molecular mechanism by which bacteria in sponges develop the ability to inhibit biofilm formation

Reveal the molecular mechanism by which bacteria in sponges develop the ability to inhibit biofilm formation

Recently, a study published in the international journal Molecular Microbiology showed that when bacteria gather somewhere, they will make a collective decision to be born on some kind of appendage or gather together and slowly swim away. This behavior was first discovered in sponges, which may help us understand how to destroy biofilms of harmful pathogenic bacteria, such as dental plaque or biofilms on internal medical devices in artificial hearts.

There are many ways for bacteria to communicate with each other. Scientists have now discovered a new type of signaling system that can encourage bacteria to produce bacterial appendages such as flagella, allowing bacteria to swim freely and inhibit the formation of bacterial biofilm . Researcher Hill said that any details we discovered about the communication of bacteria can help us understand how bacteria cause disease to humans and how bacteria form bacterial membranes inside teeth or medical devices. Understanding this process will help us effectively control the biofilm production of pathogenic bacteria.

Bacteria can gather and form biofilms in many ways, and bacteria know how to communicate to determine the body's decisions to guide them to take certain actions. This behavior system becomes quorum sensing. Special sponges include complex and different bacterial communities, and in some cases even account for 30-40% of sponge biomass. The crowd-sensing system can control a series of processes of bacterial cells, including causing bacteria to lift up and form plaque on teeth.

Bacteria that depend on sponges, when the number of bacteria reaches a certain level, they can use the group sensing system to activate their movement ability, which limits their formation of biofilms on solid surfaces. Researcher Clay Fuqua said that this behavior of the bacteria is critical to help them maintain a healthy and symbiotic flora system. Of course, the same molecular mechanism may also appear in other microbial communities, such as human intestinal microbes or microbial symbiotic plants.

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