Researchers at the Fraunhofer Institute for Laser Technology in Germany have successfully used 3D printing technology to create artificial blood vessels. This technological breakthrough is expected to be widely used in the medical fields of healing skin wounds, artificial skin reconstruction and artificial organs. Patients with major accidental injuries, extensive burns, or tumor resection often need to recreate wound skin. Current medical techniques can only artificially rebuild skin surface thickness (dermis and epidermis) up to 200 microns, but for subcutaneous tissue. A millimeter-thick intact skin system cannot be recreated because it involves vascular tissue and no nutrient supply of blood vessels. Artificial skin over 200 microns cannot survive.

To this end, the interdisciplinary team led by the Fraunhofer Institute for Laser Technology undertook the EU project "ArtiVasc 3D" to develop 3D printing technology for the manufacture of artificial blood vessels.

The key to 3D printing for the manufacture of blood vessels is to find suitable printed materials that are suitable for the physical properties and biocompatibility of transplanted blood vessels, must be compatible with endothelial and capillary surrounding tissue, and are suitable for 3D printing. To meet these conditions, the researchers used a combination of inkjet printing and stereolithography. Using this combination approach, they solved the key technology of printing porous, multi-forked artificial blood vessels that are only 20 microns thick.

The multi-fork structure of the artificial blood vessel is printed in accordance with the actual vascular structure by means of the computer's analog design. The material used to print the blood vessels is an acrylate-based synthetic polymer. This material allows the surface of blood vessels to be distributed with many micropores hundreds of microns in diameter. Using this material, the researchers successfully printed artificial blood vessels similar in function to real blood vessels for the first time.

This technology has brought good news to patients with severe skin damage such as extensive burns, as well as to patients undergoing skin reconstruction or revascularization due to surgical trauma. The researchers said that the technology is not limited to printing artificial blood vessels, but also can be used as a toolbox to select different materials, geometries and sizes for the manufacture of a variety of human tissues or human organs. The future of medical applications is very broad. .

3D printing just started to fire, everyone thought of printing human organs, and printing blood vessels is the first level of the long march. Two groups announced the successful printing of blood vessels last year. With the development of suitable materials for all walks of life, transplanting artificial blood vessels and skin is not far off. Once achieved, burns and surgical wound repair will no longer consider supply and rejection, which would be a wonderful presentation of 21st century surgical medicine.

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